A meta-analysis of randomized trials for long-term major complications following off-pump versus on-pump coronary artery bypass grafting / 天津医药

Objective To compare the long-term complications of off-pump and on-pump coronary artery bypass grafting. Methods CNKI, WanFang Data, VIP, PubMed, EMBASE and the Cochrane Central Register were searched for randomized controlled trials (RCTs) of long-term complications of off-pump and on-pump coronary artery bypass grafting. According to the Cochrane system evaluation method, the quality of the research literature was evaluated by the inclusion and exclusion criteria, and the RevMan5.2 software was used for meta analysis. Results A total of 9 studies were included, including 11 660 patients, 5 794 patients in the OPCABG group and 5 866 cases in the ONCABG group. There was no significant difference in mortality between the OPCABG group and the ONCABG group (OR=1.10, 95%CI:0.94-1.30,P=0.22] and no significant difference in myocardial infarction (OR=0.90, 95%CI:0.76-1.06,P=0.21). However, the difference in revascularization was statistically significant between the two groups (OR=1.41, 95%CI:1.09-1.83,P=0.009). The long-term incidence of stroke was significantly lower in OPCABG group than that of ONCABG group (OR=0.75, 95%CI: 0.57-0.98,P=0.04]. Conclusion The on-pump coronary artery bypass grafting can effectively reduce the occurrence of long-term revascularization. However, off-pump coronary artery bypass grafting can effectively reduce the risks of stroke.

Research Progress on the Relationship between Metabolic Syndrome and Triple-Negative Breast Cancer / 天津医药

Metabolic syndrome (MS) and breast cancer are common diseases of women. Triple negative breast cancer (TNBCs) is one type of breast cancer, which is of much attention in recent years. Important components of MS include central obesity, high blood sugar, high triglycerides and low level of high-density lipoprotein (HDL-C), which increased the inci-dence risk of TNBCs. Common biomarkers of MS including insulin, adiponectin and leptin play an important role in the oc-currence and development of breast cancer, especially TNBCs. Insulin-like growth factor-IImRNA binding protein 3 (IMP3, an oncofetal protein) may be TNBCs’new invasive cancer biomarkers. In this paper, the research progress on the relation-ship between MS and TNBCs is reviewed.